Polymeric nanoparticles are efficient in enhancing therapeutic and diagnostic effects over conventional medicines. These nanocarriers have demonstrated to decrease non-specific toxicities, improve drug delivery profiles, enhance drug stability and bioavailability, targeted drug delivery. The heat generated due to Neel and Brownian relaxation as well as hysteresis loss can be used to kill tumor cells in the vicinity of IONPs [49]. J. Pharm. Nature 196(4853), 476 (1962), S.K. Int. Nanotechnology provides high sensitivity, specificity, and multiplexed measurement capacity and has therefore been investigated for the detection of extracellular cancer biomarkers and cancer cells, as well as for in vivo imaging. Nano Lett. It is recommended that additional studies must be carried out to address the toxicity concerns, since the metal-based nanoparticles are easy to tune with the required properties for efficient loading of drugs and their potential may be excessively high in the field of biology and medicine. J. Nanomed. Int. The in vivo transplantable liver tumor bearing BALB/c nude mice treated with docetaxel loaded Gal-pD-TPGS-PLA/NPs exhibited noticeable tumor growth inhibition when compared to other nanoformulations and free Taxotere. Am. Interfaces 10, 2116021172 (2018), N. Guldris et al., Orthogonal clickable iron oxide nanoparticle platform for targeting, imaging, and on-demand release. Mater. C 79, 465472 (2017), V. Gnanavel, V. Palanichamy, S.M. However, the detection of cancer in the early stage has been hindered by the intrinsic limits of conventional cancer diagnostic methods. Chem. Macromol. National Library of Medicine J. Pharm. Release 174, 98108 (2014), S. Lakkadwala, J. Singh, Dual functionalized 5-fluorouracil liposomes as highly efficient nanomedicine for glioblastoma treatment as assessed in an in vitro brain tumor model. Multifunctional graphene smart nanomaterials have been developed for drug delivery and cellular imaging in cancer treatment [210, 213]. Acta Biomater. Zhu et al., Surface properties dictate uptake, distribution, excretion, and toxicity of nanoparticles in fish. Carbohyd. The designing of multifunctional delivery platforms using mesoporous silica nanomaterials with different characteristics is possible because of facile modification of their surface. 2, 751 (2007), V.M. In this context, Chittasupho et al., have developed CXCR4 targeted dendrimer for breast cancer therapy. In one of the recent reports the drug release and stability of pH-sensitive Au nanoparticles loaded with 5-fluorouracil capped with cetyltrimethylammonium bromide (CTAB) was achieved by incorporating into gel and cream bases [142]. Med. HHS Vulnerability Disclosure, Help Likewise, the in vivo distribution of nanoparticles indicated that highly charged nanoparticles were taken up by liver cells. Biotechnol. Nanotechnology for Treating Cancer: Pitfalls and Bridges on the Path to PMC Recently, Peng et al. Eng. Shaikh et al., Liposome co-encapsulation of synergistic combination of irinotecan and doxorubicin for the treatment of intraperitoneally grown ovarian tumor xenograft. Recently, a hybrid material based on graphene oxide (GO) coated with -cyclodextrin (CD) and poly(amido amine) dendrimer (DEN) was used to deliver doxorubicin, camptothecin (CPT) and a photosensitizer (protoporphyrin IX (PpIX)). J. Colloid Interface Sci. To date, polymeric nanomaterials, metallic nanoparticles, carbon-based materials, liposomes, and dendrimers have been developed as smart drug delivery systems for cancer treatment, demonstrating enhanced pharmacokinetic and pharmacodynamic profiles over conventional formulations due to their nanoscale size and unique physicochemical characteristics. These liposome-based combinational formulations have significant popularity due to augmented anticancer effects, antiproliferative activity, apoptosis, and cytotoxicity while diminishing the systemic toxicity. Clipboard, Search History, and several other advanced features are temporarily unavailable. J. Pharm. The advent of nanotechnology has revolutionized the arena of cancer diagnosis and treatment. 12(4), 11931202 (2015), S. Zhai et al., Visible light-induced crosslinking and physiological stabilization of diselenide-rich nanoparticles for redox-responsive drug release and combination chemotherapy. By exploiting the extended circulation property of PEGylated liposomes and biocompatibility, biodegradability and hydrophilicity of polysialic acid, a negatively charged polysaccharides drug delivery systems developed that has been used to prolong the circulation time of the liposomes, increasing the ability of epirubicin to reach the tumor sites. Eur. Control. 6 [188]. B Appl. Torchilin, New developments in liposomal drug delivery. Current trends and challenges in cancer management and - SpringerOpen Biomaterials 32(31), 80108020 (2011), S. Mignani et al., Dendrimers in combination with natural products and analogues as anti-cancer agents. J. A wide range of nanotherapeutics, composed of organic and inorganic nanomaterialshave been developed with multiple types of drugs or molecules for cancer imaging, detection and treatment. Spoial A, Ilie CI, Motelica L, Ficai D, Semenescu A, Oprea OC, Ficai A. Nanomaterials (Basel). J. Cho et al., Understanding the role of surface charges in cellular adsorption versus internalization by selectively removing gold nanoparticles on the cell surface with a I2/KI Etchant. 140, 223228 (2015), M. Jannathul Firdhouse, P. Lalitha, Apoptotic efficacy of biogenic silver nanoparticles on human breast cancer MCF-7 cell lines. The chemical changes can also introduce changes in the hydrophobicity of the polymer, changing the integrity of nanoparticles and thereby leading to release of drug cargo. J. Pharm. J. Nanomed. Sci. Cells Nanomed. Provided by the Springer Nature SharedIt content-sharing initiative. J. By using nanotechnology, nanomaterials have been developed and evaluated for cancer diagnostics. Advantage and Disadvantage in Drug Delivery Systems - ResearchGate Eng. The most striking properties of dendrimers such as branches, distinct molecular weight and globular assembly with meticulous surface functionality, and multivalency, can be exploited to be used as carriers for drug delivery [275].
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