The catalytic enantioselective oxidation is an extremely important process in organic synthesis and numbers of effort to improve this process have been reported so far. The chemical architecture of the framework Yamamoto built to stabilize the penta-coordinated carbon can be fine-tuned to stabilize other elements, such as boron, in a hypervalent state. The interdepartmental baseball game is next weekend, so the students are practicing when they have time. Prior to assuming his current role, he was Vice President, Group Strategy Office of MHI overseeing strategic planning and business promotion, including mergers and acquisitions, of the MHI Group worldwide from 2015 to 2020. Postdoctoral Scholar in Chemistry. Am. YAMAMOTO Lab. Hiro Yamamoto currently serves as President and Chief Executive Officer of MHI RJ Aviation, ULC. Dual-Activation Asymmetric Strecker Reaction of Aldimines and Ketimines Catalyzed by a Tethered Bis(8-quinolinolato) Aluminum Complex. 2011, 50, 2610 -2612. Our lab promotes both fundamental researches and applied researches. The main issues were their high and unique reactivities. Ed. We have shown that the tris(trimethylsilyl)silyl (TTMSS) silyl enol ether of acetaldehyde undergoes aldehyde cross-aldol reactions with high selectivity and the extremely low catalyst loading (0.05 mol % of HNTf2) allows for one-pot sequential reactions where acidic or basic nucleophiles can be subsequently added. reaction of tin enolates has been developed with (R)-BINAP-Silver Aldol Synthesis of Tin Enolate. Designer Acids: Combined Acid Catalysis for Asymmetric Synthesis, H. Yamamoto, K. Futatsugi, Angew. The combination of Brnsted acidity and amine moiety of enamine realizes completely regioselectivity and highly enantioselectivity. Cationic Jpn., 2007, 80, 595-607. Copyright Japan Advanced Institute of Science and Technology. Design of Chiral N-Triflyl Phosphoramide as a Strong Chiral Brnsted Acid and its application to Asymmetric Diels-Alder Reaction, Nakashima, D.; Yamamoto, H., J. Chem. Combined acid catalysis of Lewis and Brnsted acids. All Right Reserved. N.; Yamamoto, H. J. Am. Am. For homoallylic alcohols, the reaction could provide epoxy alcohols in up to 83% yield and up to 98% ee, while, for bishomoallylic alcohols, up to 79% yield and 99% ee of epoxy alcohols rather than cyclized tetrahydrofuran compounds could be obtained in most cases. Triple play: The title reaction of 1 with simple aldehydes gives 3,5,7-trisilyloxy aldehydes in high yields and diastereoselectivities with extremely low catalyst loading (see scheme). Pyrrolidine based tetrazole I have personally studied what kind of environment is suitable for the basic research. Tris(trialkylsilyl)silyl groups are easily prepared and play an important role in the selectivities of these reactions. Soc., 2011, 133, 1424814251. Futatsugi, K.; Yamamoto, H. Angew. 0000001536 00000 n Nanomaterials and Devices Research Area from April 2022. ketones. The Find contact details for 700 million professionals. A range of different elements can be supported in the center of the ring. I also support you in studying abroad or starting a venture business during or after your time in our laboratory. Am. to carbonyl group. Saadi, J.; Akakura, M.; Yamamoto, H. J. Super Brnsted Acid catalysis. Its chromium complex, TBOxCrCl, (3 mol%) effectively catalyzes the pinacol coupling reaction of aromatic aldehydes at room temperature with high yield (up to 94%), high diastereoselectivity (up to dl : meso = 98 : 2), and high enantioselectivity (up to 98%). 5735 S. Ellis Ave. (GHJ 409) Research areassurface enhanced spectroscopy, quantum optics, catalysts %PDF-1.3 % 2007 Reactions are catalyzed by C6F5CHTf2 and C6F5CTf2AlMe2 (0.5-1.5 mol%) and provide access to halogenated polyketide fragments. Am. Stereoselective Synthesis of ,-Chlorofluoro Carbonyl He is currently director of Molecular Catalyst Research Center at Chubu University. Soc. We'd go to their shows and they'd come to our shows.". O-Nitroso Aldol Synthesis. Catalytic Enantioselective Nozaki-Hiyama Allylation Reaction with Tethered Bis(8-quinolinolato) (TBOx) Chromium Complex. This method opens a new This website is using a security service to protect itself from online attacks. His other major commitment included the shareholders committee membership to Primetals Technologies, metals machinery joint venture formed by MHI and SIEMENS AG, advisory committee membership to Orano, French nuclear fuel cycle company. The band reunited in 2008. "My dad would always say some people make decisions on their ethics and they suffer for them but they are the courageous ones," Yamamoto shared. These mechanistic studies have allowed further An aluminum complex was found to be high yielding and enantioselective for the addition of cyanide to aldimines and ketimines. Catalytic Enantioselective Pudovik Reaction of Aldehydes and The chemistry I do isnt a common study area for other research groups, so there is less competition, meaning there is less time pressure. In 2016, Yamamoto co-founded the surf trio Stereo Donkey. Soc. Am. Yuko S. Yamamoto*, Tamitake Itoh*, Why and how do the shapes of surface-enhanced Raman scattering spectra change? 0000013183 00000 n Int. Equipment like this is needed to work with chemicals affected by exposure to oxygen, like the anti-aromatic porphyrin ring. October 25, 2021. To the best of my skills, research themes of students are established taking into consideration the range and direction of each students' interests and according to their preferences, with consideration of the research theme presented by me. degrees in chemistry and biochemistry, approved by the American Chemical . [1,5]- sigmatropic rearrangement yielding a ~1:1 mixture of the 1- and 2-substituted isomers. Notifications can be turned off anytime in the browser settings. Boxer, M. B.; Yamamoto, H. Org. While bond formation processes have traditionally garnered the attention of the 773.702.0805 fax.